噁唑烷酮-喹诺酮杂合物的研究进展

doi:10.11843/j.issn.0366-6964.2018.01.002

Abstract

Abstract:

Due to the increasing severity of bacterial drug resistance, the demand for novel antimicrobial agents has been growing in recent years. The multi-target hybrid which combines two kinds of drugs by a certain way provides the possibility for expanding the antibacterial spectrum, enhancing the activity against drug-resistant bacteria and reducing the frequency of bacterial resistance, and has become a new strategy to the research and development of novel antimicrobial agents. Meanwhile, oxazolidinones and quinolones with their unique mechanism of action and the complementary antibacterial spectrum attract the attention of researchers. Oxazolidinone-quinolone hybrids incorporating oxazolidinone and quinolone pharmacophores have been synthesized and shown to be active against a variety of susceptible and resistant Gram-positive and Gram-negative bacteria. In the present paper, the design, synthesis and antimicrobial activities of oxazolidinone-quinolone hybrids, and the research progress of cadazolid, a oxazolidinone-quinolone hybrid which is currently at the stage of clinical trials, are reviewed.

CLC Number:

R978.1

LIU Li-li, ZHANG Ji-yu. Advances on Oxazolidinone-quinolone Hybrids[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(1): 10-17.

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Advances on Oxazolidinone-quinolone Hybrids

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